LIPID Ligand Discovery
find lipids ligands that bind membrane readers & drug targets
find lipids ligands that bind membrane readers & drug targets
We offer biophysical instrument access, training and collaborative services for discovery of lipid ligands and small molecule drug lead candidates for membrane-associated proteins using SMALP technology and native nanodiscs.
Sets of polymer-based nanodiscs can be screened and including various lipid combinations that represent bar codes for cellular membranes and organelles.
We offer collaborative and fee-for service access to our systems including:
Our systems represent some of the latest technologies for biomolecular analysis used to screen and cross validate lipid and drug molecules, measuring their affinities and profiling ligand specificities for binding membrane proteins and native nanodiscs.
Molscreen was established by Michael Overduin and coapplicants with Canada Foundation for Innovation John R. Evans Leaders Fund grant 38496 entitled Biophysical equipment to measure complex molecular interactions in solution, which was co-funded by the Province of Alberta. This support should be acknowledged in publications and presentations that benefit.
Our team welcomes opportunities for collaboration and partnering, and has experience in setting up, running and supporting drug discovery projects focused on a range of emerging and established targets including membrane-associated proteins.